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Evaluating retinal thickness classification in children: A comparison between pediatric and adult optical coherence tomography databases.
PLoS One
January 2025
Centre for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Purpose: This study investigates the agreement of children's retinal thickness classification by color category between Topcon 3D OCT-1's built-in adult reference data and our new pediatric database and assesses the correlation of retinal thickness with age and spherical equivalent (SE).
Methods: 160 eyes of 160 healthy children (74 boys, 86 girls) aged 6-18 years (mean: 11.60 ± 3.
Analytical characteristics and performance of a new hs-cTnI method: a multicenter-study.
Clin Chem Lab Med
January 2025
Coordinator of the Italian Study Group of Cardiac Biomarkers, Scuola Superiore Sant'Anna and Fondazione CNR - Regione Toscana G. Monasterio, Pisa, Italy.
Article Synopsis
- The study aimed to assess the performance and establish the upper reference limit for high-sensitivity cardiac troponin I (hs-cTnI) using the MAGLUMI CLIA method in healthy populations.
- Two groups of healthy adults were analyzed: one with younger adults (average age 43) and another with older adults (average age 78), focusing on blood donation volunteers.
- Results showed that hs-cTnI levels were significantly higher in men than women, especially after age 55, confirming that the MAGLUMI CLIA method meets international diagnostic criteria for cardiac assessments.
Evaluation of current patient-based real-time quality control in clinical chemistry testing.
Clin Chim Acta
December 2024
Department of Clinical Chemistry, Department of Biochemistry, University of Health Sciences, Bakirköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye.
Introduction: To perform simulation studies on patient-based real-time quality control (PBRTQC) for aspartate aminotransferase (AST), iron (Fe), potassium (K), and thyrotropin (thyroid stimulating hormone, TSH) analytes, focusing on optimizing systematic error detection while minimizing data loss.
Methods: Clinical laboratory data for the four analytes were analyzed using various truncation methods. Among these methods, truncation limits corresponding to fixed percentiles (e.
Heat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability.
Environ Int
December 2024
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA; Irset Institut de Recherche en Santé, Environnement et Travail, UMR-S 1085, Inserm, University of Rennes, EHESP, Rennes, France.
Understanding effects of extreme heat across diverse settings is critical as social determinants play an important role in modifying heat-related risks. We apply a multi-scale analysis to understand spatial variation in the effects of heat across Mexico and explore factors that are explaining heterogeneity. Daily all-cause mortality was collected from the Mexican Secretary of Health and municipality-specific extreme heat events were estimated using population-weighted temperatures from 1998 to 2019 using Daymet and WorldPop datasets.
View Article and Find Full Text PDFAssay precision, 99th percentile reference value and proportion of detected healthy european adults for VIDAS® high-sensitive troponin I.
Pract Lab Med
November 2024
bioMérieux, Department of Research and Development for Immunoassays, Marcy-l'Étoile, France.
Introduction/objectives: Following the IFCC (The International Federation of Clinical Chemistry and Laboratory Medicine) guidelines concerning high-sensitivity cardiac troponin assays, we performed an assessment of the VIDAS® High-Sensitive Troponin I (TNHS) assay. The test was evaluated on its capacity to detect at least 50 % of healthy individuals and checked that the coefficient of variation was less than 10 % at the 99th percentile.
Methods: High-sensitivity performance was assessed by examining the limits of detection, the determination of the 99th percentile value, the evaluated imprecision at said value and the detectable results above limit of detection (LoD) in a cohort of healthy European individuals.
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