Aging is a multifactorial process characterized by the gradual loss of physiological functions, which leads to increased vulnerability of the organism to age-related diseases and, finally, to death. To explain the nature of aging, several theories have been proposed, one of which relates aging to damage to cell structures and DNA caused by free radicals. However, an increasing amount of evidence suggests that molecular mechanisms of aging are also associated with epigenetic modifications, such as DNA methylation, non-coding RNA and histone changes. In this review, we will analyze the significance of the results of these studies and show how the interrelated effects of oxidative stress and epigenetics can explain the cause of the extinction of physiological functions during aging.
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