AI Article Synopsis
- The ECOD project celebrates nearly 20 years of mixed manual-automatic classification of protein domains, adapting to the increasing complexity of protein structures submitted for analysis.
- Recent manual curation efforts have revealed novel homologous relationships in complex proteins, particularly in transmembrane and multidomain arrangements.
- The study introduces a new taxonomy for ABC transporter transmembrane domains, explores different structures of the leucine-specific domain in Leucine tRNA-synthetase, and discusses distant homologous connections between two helical dimerization domains.
Article Abstract
The manual classification of protein domains is approaching its 20th anniversary. ECOD is our mixed manual-automatic domain classification. Over time, the types of proteins which require manual curation has changed. Depositions with complex multidomain and multichain arrangements are commonplace. Transmembrane domains are regularly classified. Repeatedly, domains which are initially believed to be novel are found to have homologous links to existing classified domains. Here we present a brief summary of recent manual curation efforts in ECOD generally combined with specific case studies of transmembrane and multidomain proteins wherein manual curation was useful for discovering new homologous relationships. We present a new taxonomy for the classification of ABC transporter transmembrane domains. We examine alternate topologies of the leucine-specific (LS) domain of Leucine tRNA-synthetase. Finally, we elaborate on a distant homologous links between two helical dimerization domains.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588880 | PMC |
| http://dx.doi.org/10.1186/s12860-019-0204-5 | DOI Listing |
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