The dosimetric leaf gap (DLG) and tongue-and-groove (T&G) effects are critical aspects in the modeling of multileaf collimators (MLC) in the treatment planning system (TPS). In this study, we investigated the dosimetric impact of limitations associated with the T&G modeling in stereotactic plans and its relationship with the need for tuning the DLG in the Eclipse TPS. Measurements were carried out using Varian TrueBeam STx systems from two different institutions. Test fields presenting MLC patterns with several MLC gap sizes (meanGap) and different amounts of T&G effect (TGi) were first evaluated. Secondly, dynamic conformal arc (DCA) and volumetric modulated arc therapy (VMAT) deliveries of stereotactic cases were analyzed in terms of meanGap and TGi. Two DLG values were used in the TPS: the measured DLG (DLG ) and an optimal DLG (DLG ). Measured and calculated doses were compared according to dose differences and gamma passing rates (GPR) with strict local gamma criteria of 2%/2 mm. The discrepancies were analyzed for DLG and DLG , and their relationships with both TGi and meanGap were investigated. DCA arcs involved significantly lower TGi and larger meanGap than VMAT arcs (P < 0.0001). By using DLG in the TPS, the dose discrepancies increased as TGi increased and meanGap decreased for both test fields and clinical plans. Dose discrepancies dramatically increased with the ratio TGi/meanGap. Adjusting the DLG value was then required to achieve acceptable calculations and configuring the TPS with DLG led to an excellent agreement with median GPRs (2%/2 mm) > 99% for both institutions. We also showed that DLG could be obtained from the results of the test fields. We demonstrated that the need for tuning the DLG is due to the limitations of the T&G modeling in the Eclipse TPS. A set of sweeping gap tests modified to incorporate T&G effects can be used to determine the optimal DLG value.
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http://dx.doi.org/10.1002/acm2.12656 | DOI Listing |
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November 2024
Laboratory of Chemistry and Technology of Polymers and Colors, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Greece.
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January 2025
From the Institute for Memory Impairments and Neurological Disorders (J.D.G., S.T., G.T., B.V., K.G., D.L.G.), University of California, Irvine; Department of Psychiatry and Human Behavior (J.D.G.), University of California, Irvine; Department of Neurobiology and Behavior (J.D.G., K.G.), University of California, Irvine; Division of Geriatric Medicine (S.T.), Department of Medicine, University of California, Irvine; Department of Neurology (G.T.), University of California, Irvine; Department of Neurology (A.L.P.), Oregon Health and Science University; Department of Statistics (D.L.G.), University of California, Irvine; Department of Neurology and Neurological Sciences (E.T.), Stanford University; Department of Neurology (S.K.), Cedars Sinai Medical Center; Department of Neurology (M.B.), University of California, Los Angeles; Alzheimer's Disease Cooperative Study (R.A.R., G.C.L., A.B., C.R., R.M., R.J., J.P., J.Z., S.J., K.M., H.H.F.), University of California, San Diego; and Department of Neurosciences (G.C.L., J.P., H.H.F.), University of California, San Diego.
Background And Objectives: Nicotinamide is a coenzyme involved in cellular oxidation-reduction reactions that can inhibit Class III histone deacetylases (HDACs) or sirtuins. HDAC inhibition can affect numerous therapeutic pathways, including tau phosphorylation. We tested the hypothesis that nicotinamide treatment could reduce tau phosphorylation in early Alzheimer disease (AD).
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Department of Otorhinolaryngology, Kocaeli City Hospital, Kocaeli, Türkiye.
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Department of Radiation Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
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View Article and Find Full Text PDFZhonghua Wai Ke Za Zhi
December 2024
Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing100038, China.
To investigate the clinical features of primary intestinal lymphangiectasia (PIL). This study was a retrospective case series study. Fifty consecutive patients diagnosed with PIL in Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University from March 2019 to March 2021 were included and their clinical data was retrospectively reviewed.
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