AI Article Synopsis
- Mitochondrial bioenergetics rely on coordination between two distinct genomes, and mutations in either can disrupt mitochondrial function, leading to cellular stress.
- The type of defect and resulting stress can impact various tissues and organs, leading to a range of health issues associated with mitochondrial diseases.
- While there's no cure for these diseases, there are strategies available to combat the different forms of stress arising from dysfunctional mitochondria.
Article Abstract
Mitochondrial bioenergetics require the coordination of two different and independent genomes. Mutations in either genome will affect mitochondrial functionality and produce different sources of cellular stress. Depending on the kind of defect and stress, different tissues and organs will be affected, leading to diverse pathological conditions. There is no curative therapy for mitochondrial diseases, nevertheless, there are strategies described that fight the various stress forms caused by the malfunctioning organelles. Here, we will revise the main kinds of stress generated by mutations in mitochondrial genes and outline several ways of fighting this stress.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551628 | PMC |
| http://dx.doi.org/10.15698/cst2018.07.147 | DOI Listing |
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