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Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model.
J Neuroinflammation
March 2025
MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Department of Cell Biology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in the literature. Numerous studies have demonstrated that the activation of the epidermal growth factor receptor 4 (ErbB4) is crucial in neuronal injury and regeneration processes. This study investigated the role of targeted activation of ErbB4 receptor through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), in mitigating PS-MPs-induced neuronal injury.
View Article and Find Full Text PDFNNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.
Mol Cancer
March 2025
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are remarkably effective for treating EGFR-mutant non-small cell lung cancer (NSCLC). However, patients inevitably develop acquired drug resistance, resulting in recurrence or metastasis. It is important to identify novel effective therapeutic targets to reverse acquired TKI resistance.
View Article and Find Full Text PDFPhylogenetic analysis and transmission networks highlight the role of older adults in the transmission of HIV-1 in northern Zhejiang, China.
Virol J
March 2025
Department of AIDS and STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou, Zhejiang Province, 310051, P. R. China.
Background: In China, human immunodeficiency virus (HIV) poses a significant challenge to older heterosexual adults. This study explored the transmission dynamics of HIV infection among older adults in northern Zhejiang Province, China using phylogenetic analysis and transmission networks.
Methods: HIV pol sequences without any antiretroviral therapy were obtained from newly diagnosed HIV-positive patients in Huzhou between 2017 and 2022.
Executive functions in everyday life in children born small for gestational age - a pilot study of pre-term to full-term children 3 years and younger.
BMC Pediatr
March 2025
Faculty of Health and Life Sciences, MEO, Linnaeus University, Kalmar, Region Kalmar County, Sweden.
Background: Children born small for gestational age (SGA) have shown an increased risk of developing cognitive impairment and more difficulties regarding academic performance later in life. However, it is not known whether cognitive impairment can be detected in very young children. This study aimed to investigate whether children born SGA, with a birthweight of ≤ 3 SD, aged 2:6-3:0 years, showed impairments of executive functions in everyday life based on parental ratings, compared to children born appropriate for gestational age (AGA).
View Article and Find Full Text PDFA comparison of two cleaning methods applied in a small animal hospital.
BMC Vet Res
March 2025
Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, 750 07, Sweden.
Background: Environmental cleaning of near-patient surfaces in animal healthcare is an important infection prevention and control measure to lower the risk of spread of healthcare-associated infections (HAIs). There is a lack of reports on the effect of cleaning of near-patient surfaces in animal hospital wards. The aims of this study were to (1) determine bacterial load before cleaning, on near-patient surfaces in dog cages in a mixed medical and surgical ward and investigate factors associated with this bacterial load (2) compare the bacterial reduction on these surfaces after cleaning with (a) a scrubbing brush with detergent and rinsing before and after cleaning, and (b) a microfibre mop moistened with water, and after disinfection carried out after each cleaning method.
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