Non-ionizing, laser radiation in Theranostics: The need for dosimetry and the role of Medical Physics.

The discovery of coherent laser light in 1960 shifted and expanded the biomedical applications of radiation to the non-ionizing part of the electromagnetic spectrum. As in the case of ionizing radiation, but considering the laser specific features, the effective, safe and ethically acceptable use of biomedical laser technology requires interdisciplinary collaboration between physicists, engineers and physicians. This should extend at the research, preclinical and clinical level, inspiring at this time the dynamic discipline of Medical Physics in new areas. With this work we aim to introduce the interested reader in the need of dosimetry in medical applications of laser radiation, as this field is still unexplored. After some necessary definitions, we give a brief review of the basic biophysical mechanisms of coherent light-matter interactions. The manuscript focuses on biomedical laser applications in diagnosis and therapy (i.e. in Theranostics). From the vast field of laser theranostic applications we have chosen some experimental and theoretical results - examples of quantification of the laser effect, particularly relevant to soft and hard tissue laser ablation, laser induced photodiagnosis and photodynamic therapy of cancer. These topics intend to highlight the important role of Medical Physicists in the optimization of well-established laser based clinical procedures and mainly emerge the necessity of the relevant dosimetry for each application. Finally, we hope that this effort is going to give food for thought and highlight the importance of deep knowledge of the physics behind some everyday medical applications.