Bacterial infections are a growing global challenge for public health as antibiotic resistance could cause the failure of anti-infective treatment eventually. So, it is urgent to develop new potential antibacterial materials. Herein, a multifunctional chitosan (CS) functionalized magnetic Chlorin e6 (CS-MP-Ce6) was constructed to combat methicillin-resistant Staphylococcus aureus (MRSA) infection by integrating bacterial conjugation and enrichment, and near-infrared (NIR)-triggered photodynamic sterilization. CS-MP-Ce6 could efficiently capture bacteria due to positively charged property of CS, and Ce6 acted as an effective photodynamic killer to convert NIR light into local energy to enhance antibacterial activity. Specifically, after being trapped together with MRSA, CS-MP-Ce6 showed an excellent in vitro photodynamic sterilization ability. In vivo MRSA-induced abscess treatment studies showed faster healing when CS-MP-Ce6 was used as subcutaneous nano-localized energy sources with the assistance of external magnet to concentrate CS-MP-Ce6-bacteria conjugate. This work provides a promising framework for constructing a new system for efficiently combating MRSA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2019.05.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hybrids of copper cysteamine nanosheets and silver nanocluster ensure superior bactericidal capability via enhanced photodynamic effect.
Sci Rep
December 2024
School of Biomedical Sciences, Suzhou Chien-shiung Institute of Technology, Suzhou, 215411, People's Republic of China.
Over the past decades, bacterial infections resulting from the misuse of antibiotics have garnered significant attention. Among the alternative antibacterial strategies, photodynamic therapy (PDT) has emerged as a promising non-antibiotic approach. However, persistent bacterial biofilms, particularly those composed of gram-negative bacteria with their protective outer membranes, have exhibited remarkable resilience to PDT.
View Article and Find Full Text PDFMultifunctional Fluorescent Material Based Red-emitting Carbon Dots for Cell Imaging and Photodynamic Sterilization.
Chem Asian J
December 2024
Northwest Normal University, College of Chemistry and Chemical Engineering, CHINA.
In this paper, a new carbon dot (R1-CDs) was prepared by one-pot hydrothermal method by using 1,8-diaminonaphthalene and o-phthalic acid (o-PA) as precursors. Due to the high purity of R1-CDs, NMR analysis was performed to identify the types of H and C atoms in their graphene sheets. From our research findings, three important information was disclosed such as (1) five types H atoms are presented in R1-CDs; (2) 18 kinds of C atoms in the graphene sheets are observed, and 8 kinds of them are quaternary atoms, and 10 kinds of carbon atoms as tertiary one; (3) functional groups of -COOH and -NH2 from precursors cannot be inherited into the edges or defect sites of graphene sheet.
View Article and Find Full Text PDFAggregation-Induced Emission Luminogens for Plant Photodynamic Seed Sterilization.
Small
December 2024
School of Food and Biological Engineering, Anhui Provincial International Science and Technology Cooperation Base for Major Metabolic Diseases and Nutritional Interventions, Hefei University of Technology, Hefei, 230009, P. R. China.
Pathogen-carrying seeds can significantly impact plant growth and development and may lead to serious public health incidents. Modern agriculture heavily relies on synthetic chemical microbicides and physical methods to eradicate pathogens transmitted by plant seeds. To counteract the misuse of microbicides, a class of cationic amphiphilic aggregate-induced emission luminogens (AIEgens) are developed as photodynamic seed sterilization agents.
View Article and Find Full Text PDFNatural borneol improves cellular uptake of curcumin to enhance its photodynamic bactericidal activity against Escherichia coli ATCC 8739.
Food Microbiol
April 2025
School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China; China-Singapore International Joint Research Institute, Guangzhou, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. Electronic address:
Photodynamic inactivation (PDI), a non-thermal sterilization method, has attracted considerable attention due to its broad-spectrum antimicrobial activity, environmental friendliness and cost-effectiveness. Curcumin (Cur), a food-grade photosensitizer, exhibits photodynamic antimicrobial activity based primarily on its efficiency in intracellular accumulation. However, Cur's low water solubility and the barriers presented by the outer membrane of Gram-negative bacteria challenge its ability to penetrate the cytoplasm.
View Article and Find Full Text PDFNear-field coupling resonance enhancement with AuNiO Heterostructure nanosheets for high-performance photodynamic/photothermal Hybrid antibacterial & imaging tracking.
Biosens Bioelectron
March 2025
Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China. Electronic address:
Bacterial infection has always been a serious public health problem worldwide. Real-time microbial monitoring in the trauma resuscitation unit is crucial for infection control and plays an essential role in all aspects of wound treatment clinical practice, such as identification and evaluation of wound infection, diagnosis of wound infection, and topical antimicrobial treatment. Herein, gold-loaded nickel oxide nanosheets (Au-NiO NSs) prepared by hydrothermal and laser-assisted synthesis methods are used as fluorescent nanoprobes to rapidly detect and target bacteria at an early stage, and then achieve combined PTT and PDT to inactivate bacteria under sunlight.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!