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Clozapine-Associated Myoclonus and Stuttering Secondary to Smoking Cessation and Drug Interaction: A Case Report.

J Clin Psychopharmacol

August 2019

Department of Psychiatry, Medstar Georgetown University Hospital, Washington, DC Department of Neurology, Department of Veterans Affairs Medical Center of Washington DC and Department of Neurology, George Washington University Hospital, Washington, DC Department of Psychiatry, Department of Veterans Affairs Medical Center of Washington DC, Department of Psychiatry, George Washington University Hospital, Washington, DC Department of Neurology, Medstar Georgetown University Hospital, Washington, DC

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There is limited literature reporting clozapine-associated stuttering. In this case report, we present a case of a young male who developed stuttering with clozapine, which improved with dose reduction. Computer-assisted searches on clozapine-induced stuttering yielded 16 cases, and analysis of these case reports suggests that stuttering may be linked to seizures or movement disorders, but other putative mechanisms may be at work, which need further research.

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