AI Article Synopsis
- The study investigates the transdermal effects of collagen hydrolysates extracted from deer sinew, which contains a high collagen content of 82.12%.
- The research assesses how effectively these hydrolysates can penetrate mouse skin and their impact on skin protection through antioxidant properties and collagen secretion in cells.
- Results indicate that around 8% of the collagen hydrolysates can penetrate the skin, promoting cell growth and collagen production, suggesting their potential use in cosmetics for skin protection against aging.
Article Abstract
Background: The collagen hydrolysates as a cosmetic material have already been wide application. At present, few studies concern with transdermal behavior of collagen hydrolysates in vitro.
Objective: Deer sinew contains rich collagen with a content of 82.12%. Thus, this article mainly studies the transdermal effect of collagen hydrolysates of deer sinew (DSCH) on mouse skin, ex vitro, and to explore skincare protection of percutaneous proteins.
Methods: Collagen hydrolysates of deer sinew were extracted by 0.2% HCl and a two-step enzymatic method of pepsin-trypsin. The content of 17 amino acids of DSCH was detected by precolumn derivatization RP-HPLC. Using Franz diffusion cell systems studied the transdermal effect of DSCH and then examined the percutaneous rate and molecular weight distribution of percutaneous proteins (PP). Further, we studied the bioactivity of PP in vitro, such as the total antioxidant capacity and collagen secretion in NIH/3T3 cells.
Results: About 8.0% DSCH could penetrate skin of mouse, the molecular weight of PP mainly distributed in 5 ~ 13 kDa, accounted for 91.55%. Compared with the antioxidant activity of DSCH, PP had obvious antioxidant activity of scavenging radical cation. Meanwhile, PP promoted cell proliferation and collagen I secretion in fibroblast cells; however, level of type III collagen has no change.
Conclusion: Collagen hydrolysates of deer sinew may be used as cosmetic material to protect the skin from oxidative stress, to prevent premature skin aging.
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| http://dx.doi.org/10.1111/jocd.13041 | DOI Listing |
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