The Avidity Game: Selecting Natural-Born Killers.

Immunity

Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; Centre for Experimental Immunology, Lions Eye Institute, Perth, WA, Australia. Electronic address:

Published: June 2019

Natural killer (NK) cells display some features equivalent to those of adaptive immune effectors, but the molecular processes underlying these adaptive-like characteristics are just beginning to be defined. In this issue of Immunity, Adams et al. (2019) and Grassmann et al. (2019) report that avidity selection for Ly49H governs the expansion, differentiation, and function of NK cells after cytomegalovirus infection.

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Source
http://dx.doi.org/10.1016/j.immuni.2019.05.018DOI Listing

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