This is a review summarizing the development of vestibulo-ocular reflex (VOR) adaptation behavior with relevance to rehabilitation over the last 10 years and examines VOR adaptation using head-on-body rotations, specifically the influence of training target contrast, position and velocity error signal, active vs. passive head rotations, and sinusoidal vs. head impulse rotations. This review discusses optimization of the single VOR adaptation training session, consolidation between repeated training sessions, and dynamic incremental VOR adaptation. Also considered are the effects of aging and the roles of the efferent vestibular system, cerebellum, and otoliths on angular VOR adaptation. Finally, this review examines VOR adaptation findings in studies using whole body rotations.
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http://dx.doi.org/10.1152/jn.00729.2018 | DOI Listing |
Nat Commun
January 2025
Center for Early Detection and Interception of Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Early therapeutic intervention in high-risk smoldering multiple myeloma (HR-SMM) has shown benefits, however, no studies have assessed whether biochemical progression or response depth predicts long-term outcomes. The single-arm I-PRISM phase II trial (NCT02916771) evaluated ixazomib, lenalidomide, and dexamethasone in 55 patients with HR-SMM. The primary endpoint, median progression-free survival (PFS), was not reached (NR) (95% CI: 57.
View Article and Find Full Text PDFMMW Fortschr Med
December 2024
Heinrich-Braun-Klinikum Zwickau, ChA der Klinik f. Psychiatrie u. Psychotherapie, Karl-Keil-Str. 35, 8060, Zwickau, Deutschland.
Background: Many former top GDR athletes are still suffering from the consequences of the GDR doping system, which has so far been dealt with by the sports historian Giselher Spitzer in particular with questionnaire surveys. The present study analyzes medical reports of n = 107 recognized GDR doping victims, categorizes the symptoms in analogy to Spitzer's survey and compares both surveys.
Method: All specialist reports, hospital and rehabilitation stay reports of the recognized doping victims (56 ♀ , 51 ♂ ) provided were reviewed, analyzed, adapted to Spitzer's previously known rubrication, presented descriptively, tabularly and graphically and statistically tested (e.
Dermatologie (Heidelb)
January 2025
Abteilungen für Dermatologie, Venerologie, Allergologie und Immunologie, Dessau Medical Center, Brandenburg Medizinische Hochschule Theodor Fontane, Auenweg 38, 06847, Dessau, Deutschland.
Diabetes mellitus (DM) is a debilitating, life-limiting disease. According to recent estimates, 415 million adults currently suffer from the disease. This number is expected to rise to 642 million by 2040.
View Article and Find Full Text PDFOphthalmologie
December 2024
Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
Objective Of Surgery: The aim of endothermal pupilloplasty (EP) is to optimize centering of the pupil, contour, or size.
Indications: The EP is performed in patients with congenital or acquired corectopia or an irregular pupil shape. In individual cases the technique has also been used to tighten the iris in floppy iris syndrome and to adapt iris tissue edges in patients with sectoral iris defects or iridodialysis.
J Fungi (Basel)
November 2024
Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Many microbial pathogens form biofilms, assemblages of polymeric compounds that play a crucial role in establishing infections. The biofilms of species also contribute to high antifungal resistance. Using our collection of 29 clinical isolates, we focused on characterizing differences in thermotolerance, anaerobic growth, and biofilm formation across four species complexes commonly found in clinical settings.
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