Research indicates that episodic memory processes are required to access specific autobiographical events and the details encompassed by a single event for several functions, including remembering and personal problem solving. Since healthy cognitive aging is associated with episodic memory decline, we hypothesized that older adults would be impaired at producing specific autobiographical events and details in service of these two functions. To test this hypothesis, younger and older adults completed two tasks (generation and elaboration) across two experiments (autobiographical memory and problem solving). The generation task required participants to produce multiple specific event memories or solutions to cues within a 90-s time period. The elaboration task required participants to select a single memory or solution to describe in detail. We quantified the number of specific and non-specific responses provided during the generation task and scored the descriptions from the elaboration task for the number of episodic (internal) and non-episodic (external) details. Across experiment, older adults produced fewer specific responses (generation task) and fewer internal details (elaboration task) than younger adults. In addition, older adults generated more non-specific responses and external details than younger adults for the memory but not the problem-solving experiment. A correlational analysis showed that the number of specific responses (generation) and internal details (elaboration) correlated for the memory but not for the problem-solving experiment. These results show that age-related episodic memory decline impairs access to specific autobiographical events and detail information when remembering and problem solving, but that additional cognitive factors impact how these age declines present when solving problems.
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http://dx.doi.org/10.3758/s13421-019-00953-1 | DOI Listing |
Asian J Endosc Surg
January 2025
Department of Surgery, Nishichita General Hospital, Tokai, Aichi, Japan.
Fistulization involving both the sigmoid colon and urachus is exceedingly rare. While previous cases have often necessitated laparotomy due to the involvement of multiple organs, only one instance of successful laparoscopic surgery has been reported. Here, we present the second documented case of laparoscopic resection of a sigmoid-urachal fistula.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
Nursing Science (INS), Department Public Health (DPH), Faculty of Medicine, University of Basel, Basel, Switzerland.
Aim: To implement and evaluate an Advanced Practice Nurse-led transitional care model (AdvantAGE) to reduce rehospitalisation rates in frail older adults discharged from a Swiss geriatric hospital.
Design: The study adopts an effectiveness-implementation hybrid design (Type 1) to simultaneously evaluate the effectiveness of the care model and explore the implementation process.
Methods: The primary outcome, the 90-day rehospitalisation rate, will be evaluated using a matched-cohort design with a prospective intervention group and a retrospective control group.
Cancer
February 2025
General Medicine Service, VA Puget Sound Health Care System, Seattle, Washington, USA.
Background: Breast cancer screening (BCS) inequities are evident at national and local levels, and many health systems want to address these inequities, but may lack data about contributing factors. The objective of this study was to inform health system interventions through an exploratory analysis of potential multilevel contributors to BCS inequities using health system data.
Methods: The authors conducted a cross-sectional analysis within a large academic health system including 19,774 individuals who identified as Black (n = 1445) or White (n = 18,329) race and were eligible for BCS.
Cancer
February 2025
Departmental Unit of Molecular and Genomic Diagnostics, Genomics Core Facility, G-STeP, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Background: To date, 11 DNA polymerase epsilon (POLE) pathogenic variants have been declared "hotspot" mutations. Patients with endometrial cancer (EC) characterized by POLE hotspot mutations (POLEmut) have exceptional survival outcomes. Whereas international guidelines encourage deescalation of adjuvant treatment in early-stage POLEmut EC, data regarding safety in POLEmut patients with unfavorable characteristics are still under investigation.
View Article and Find Full Text PDFCancer Med
February 2025
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Introduction: Immune checkpoint inhibitors (ICI) have improved the therapeutic arsenal in outpatient oncology care; however, data on necessity of hospitalizations associated with immune-related adverse events (irAEs) are scarce. Here, we characterized hospitalizations of patients undergoing ICI, from the prospective cohort study of the immune cooperative oncology group (ICOG) Hannover.
Methods: Between 12/2019 and 06/2022, 237 patients were included.
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