The average fitness difference between adjacent sites in a fitness landscape is an important descriptor that impacts in particular the dynamics of selection/mutation processes on the landscape. Of particular interest is its connection to the error threshold phenomenon. We show here that this parameter is intimately tied to the ruggedness through the landscape's amplitude spectrum. For the NK model, a surprisingly simple analytical estimate explains simulation data with high precision.
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http://dx.doi.org/10.1007/s12064-019-00296-0 | DOI Listing |
Alzheimers Dement
December 2024
455 Broadway St., Redwood City, CA, USA.
Background: A potential mechanism underpinning the cognitive benefits from physical activity and aerobic exercise is cardiorespiratory fitness (CRF). Greater cardiorespiratory fitness (CRF) was associated with better executive function, short-term memory, and global cognition in older adults without cognitive impairment. Sex differences in CRF has been established in adults.
View Article and Find Full Text PDFComput Biol Med
January 2025
Department of Simulation and Graphics, Faculty of Computer Science, University of Magdeburg, Universitätsplatz 2 39106, Magdeburg, Germany; Department of Computational Medicine, Ilmenau University of Technology, Germany.
Purpose: This paper presents a deep learning-based multi-label segmentation network that extracts a total of three separate adipose tissues and five different muscle tissues in CT slices of the third lumbar vertebra and additionally improves the segmentation of the intermuscular fat.
Method: Based on a self-created data set of 130 patients, an extended Unet structure was trained and evaluated with the help of Dice score, IoU and Pixel Accuracy. In addition, the interobserver variability for the decision between ground truth and post-processed segmentation was calculated to illustrate the relevance in everyday clinical practice.
Br J Sports Med
January 2025
Wits Sport and Health (WiSH), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Objectives: This study aimed to determine the association between progression and mortality in individuals with stage 1 cancer and their recorded physical activity before the diagnosis of the cancer.
Methods: We included 28 248 members with stage 1 cancers enrolled in an oncology programme in South Africa. Physical activity was recorded using fitness devices, logged gym sessions and participation in organised fitness events.
Pathogens
December 2024
Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Celoria 2, 20133 Milan, Italy.
is an important plant pathogen in maize and other cereals that is seldom detected as the cause of human fusariosis. Here, we provide the analysis of the available diversity of sequenced worldwide and report the first two genome assemblies and annotations (including mitochondrial DNA) of from clinical settings. 05-0160 (IUM05-0160) and 09-1037 (IUM09-1037) strains were obtained from the bone marrow and blood of two immunocompromised patients, respectively.
View Article and Find Full Text PDFChildren (Basel)
December 2024
Department of Pediatrics, Federal University of Paraná, Curitiba 80060-000, PR, Brazil.
Background/objectives: The associations between low birth weight (LBW) and the aggregation of metabolic risk factors (MRF) in youth remain ambiguous. Thus, this study analysed the interrelationship among MRF, LBW, and behavioural factors in adolescents.
Methods: The sample of the present cross-sectional study comprised 491 youth (229 males, 262 females) aged 14-17 years.
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