New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies.

Chem Soc Rev

Universität Leipzig, Fakultät für Chemie und Mineralogie, Institut für Anorganische Chemie, Johannisallee 29, 04103 Leipzig, Germany.

Published: July 2019

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.

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Source
http://dx.doi.org/10.1039/c9cs00197bDOI Listing

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