AI Article Synopsis
- Researchers achieved effective gene knockdown in normal human bronchial epithelium (NHBE) cells, which are covered in mucus, using a specific technique.
- The method involved guanylurea functionalization, which alters the chemical properties of the gene carrier.
- This study highlights a promising approach for targeting genes in complex environments like the lungs, which could have implications for respiratory therapies.
Article Abstract
We demonstrate a successful target gene knockdown in ex vivo normal human bronchial epithelium (NHBE) cells covered with mucus layers using the guanylurea functionalization technique modulating the chemical environment at the positive charge of a gene carrier.
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| http://dx.doi.org/10.1039/c9cc02856k | DOI Listing |
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Article Synopsis
- Researchers achieved effective gene knockdown in normal human bronchial epithelium (NHBE) cells, which are covered in mucus, using a specific technique.
- The method involved guanylurea functionalization, which alters the chemical properties of the gene carrier.
- This study highlights a promising approach for targeting genes in complex environments like the lungs, which could have implications for respiratory therapies.
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