Demonstration of -V600E in Rosai-Dorfman-Destombes disease requires sensitive molecular assays and molecular-based tissue immunostain. -V600E blood testing is important for disease-monitoring -mutated histiocytosis and can guide inhibitor treatment plans.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595264PMC
http://dx.doi.org/10.1182/bloodadvances.2019000093DOI Listing

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