Two-dimensional Simulation of Motion of Red Blood Cells with Deterministic Lateral Displacement Devices.

Deterministic lateral displacement (DLD) technology has great potential for the separation, enrichment, and sorting of red blood cells (RBCs). This paper presents a numerical simulation of the motion of RBCs using DLD devices with different pillar shapes and gap configurations. We studied the effect of the pillar shape, row shift, and pillar diameter on the performance of RBC separation. The numerical results show that the RBCs enter "displacement mode" under conditions of low row-shift (∆ < 1.4 µm) and "zigzag mode" with large row shift (∆ > 1.5 µm). RBCs can pass the pillar array when the size of the pillar ( > 6 µm) is larger than the cell size. We show that these conclusions can be helpful for the design of a reliable DLD microfluidic device for the separation of RBCs.