Variable and Variant Protein Multigene Families in Persistence.

Pathogens

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32611, USA.

Published: June 2019

Cattle infected with face a bifurcated fate: Either die of the severe acute infection, or survive and carry for many years a highly persistent but generally asymptomatic infection. In this review, the author describes known and potential contributions of three variable or highly variant multigene-encoded families of proteins to persistence in the bovine host, and the mechanisms by which variability arises among these families. Ramifications arising from this variability are discussed.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630957PMC
http://dx.doi.org/10.3390/pathogens8020076DOI Listing

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