Prognostic Implications of Tripartite Motif Containing 24 Expression Levels in Patients with Solid Tumors: A Systematic Review and Meta-Analysis.

To systematically investigate the prognostic implications of tripartite motif containing 24 () expression levels in Patients with solid tumors. Pubmed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched through December 2017 to identify studies examining the relationship between expression levels and outcomes in solid tumor patients. The hazard ratios (HRs) with corresponding 95% confidence intervals were used to evaluate the association between and overall survival (OS). Ten studies with 1370 patients were included. The overall pooled prevalence for overexpression was 59.0% ( < 0.01). Moreover, the pooled HR of for OS was 0.43 ( = 0.04) by univariate analysis in 10 articles (1370) and 0.62 ( = 0.08) by multivariate analysis in 5 studies (845). over-expression was associated with tumor invasiveness (odds ratio [OR] = 2.05,  < 0.01) and tumor-node-metastasis stage (OR = 2.42,  = 0.03). This study demonstrated that expression levels may be a useful prognostic biomarker in patients with solid tumors.