AI Article Synopsis
- Polycystic ovary syndrome (PCOS) affects 4-21% of women of reproductive age, and recent findings suggest that women with PCOS might have a lower risk of invasive ovarian cancer, but the accuracy of self-reported PCOS is uncertain.
- Researchers used genetic markers to perform Mendelian randomization and investigated the association between genetically predicted PCOS and ovarian cancer risk in a large European ancestry population.
- The study found a significant inverse relationship, showing that women with genetically predicted PCOS had a lower risk of invasive ovarian cancer, especially endometrioid tumors, suggesting the need for further research to explore the underlying mechanisms.
Article Abstract
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. Recently, the Ovarian Cancer Association Consortium (OCAC) reported a decreased risk of invasive ovarian cancer among women with self-reported PCOS. However, given the limitations of self-reported PCOS, the validity of these observed associations remains uncertain. Therefore, we sought to use Mendelian randomization with genetic markers as a proxy for PCOS, to examine the association between PCOS and ovarian cancer.
Methods: Utilizing 14 single nucleotide polymorphisms (SNPs) previously associated with PCOS we assessed the association between genetically predicted PCOS and ovarian cancer risk, overall and by histotype, using summary statistics from a previously conducted genome-wide association study (GWAS) of ovarian cancer among European ancestry women within the OCAC (22 406 with invasive disease, 3103 with borderline disease and 40 941 controls).
Results: An inverse association was observed between genetically predicted PCOS and invasive ovarian cancer risk: odds ratio (OR)=0.92 [95% confidence interval (CI)=0.85-0.99; P = 0.03]. When results were examined by histotype, the strongest inverse association was observed between genetically predicted PCOS and endometrioid tumors (OR = 0.77; 95% CI = 0.65-0.92; P = 0.003). Adjustment for individual-level body mass index, oral contraceptive use and parity did not materially change the associations.
Conclusion: Our study provides evidence for a relationship between PCOS and reduced ovarian cancer risk, overall and among specific histotypes of invasive ovarian cancer. These results lend support to our previous observational study results. Future studies are needed to understand mechanisms underlying this association.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659359 | PMC |
| http://dx.doi.org/10.1093/ije/dyz113 | DOI Listing |
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