AI Article Synopsis
- Two new cationic surfactants were created and analyzed using techniques like FT-IR and NMR spectroscopy, as well as methods to measure their critical micelle concentration (CMC).
- The surfactants were studied for their interactions with two anionic drugs, diclofenac and ketoprofen, assessing their binding constants and effects on drug solubility and bioavailability.
- Additionally, the surfactants were evaluated for their effectiveness as carriers for bioactive zinc complexes and tested for their anti-fungal and anti-bacterial properties.
Article Abstract
Two new cationic surfactants, n-hexadecyl-3-methylpyridinium bromide and n-heptadecyl-3-methylpyridinium bromide have been synthesized and characterized in solid state by FT-IR, and in solution by H- and C-NMR spectroscopy. The values of critical micelle concentration (CMC) were determined by UV-visible spectroscopy and conductometry. Interaction of synthesized surfactants with two anionic drugs, i.e., diclofenac sodium {[2-(2, 6-Dichloroanilino) phenyl] acetic acid} and ketoprofen [(RS)-2-(3-benzoylphenyl) propionic acid] was studied by UV-visible spectroscopy. Binding constant (K), Gibb's free energy (ΔG) and number of drug molecules (n) per micelle were also calculated. These synthesized surfactants were proved to be efficient in increasing the solubility and bioavailability of drug molecules. In order to check the carrier efficiency of synthesized surfactants against bioactive coordinate, on complexes, interaction of recently reported bioactive zinc complexes was tested with synthesized cationic surfactants by conductometric measurements. Mole fractions (X) and Gibbs free energy (ΔG) values were also calculated. Both surfactants were further screened for anti-fungal and anti-bacterial activities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562109 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2019.e01885 | DOI Listing |
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