AI Article Synopsis
- Pulmonary infections are tough to treat because of intrinsic multidrug resistance.
- Previous research showed that bedaquiline works well against resistant strains.
- This study finds that verapamil boosts bedaquiline's effectiveness against these infections, suggesting it could be a helpful addition to treatment if delivered safely at high doses.
Article Abstract
Due to intrinsic multidrug resistance, pulmonary infections with are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against both and Here, we report that verapamil improves the efficacy of bedaquiline activity against clinical isolates and low-level resistant strains, both and in macrophages. Verapamil may have clinical potential as adjunctive therapy provided that sufficiently high doses can be safely achieved.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709475 | PMC |
| http://dx.doi.org/10.1128/AAC.00705-19 | DOI Listing |
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