Modern imaging of pituitary adenomas.

Best Pract Res Clin Endocrinol Metab

Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address:

Published: April 2019

AI Article Synopsis

  • Effective decision-making for pituitary disease relies on high-quality imaging of the sella and surrounding areas, with MRI being the preferred method.
  • Standard T1 and T2 weighted MRI sequences generally provide sufficient information for planning treatments like surgery, radiotherapy, and medical therapy.
  • However, in some cases, additional imaging techniques or functional/molecular imaging might be necessary to guide therapy choices for patients with pituitary adenomas.

Article Abstract

Decision-making in pituitary disease is critically dependent on high quality imaging of the sella and parasellar region. Magnetic resonance imaging (MRI) is the investigation of choice and, for the majority of patients, combined T1 and T2 weighted sequences provide the information required to allow surgery, radiotherapy (RT) and/or medical therapy to be planned and long-term outcomes to be monitored. However, in some cases standard clinical MR sequences are indeterminate and additional information is needed to help inform the choice of therapy for a pituitary adenoma (PA). This article reviews current recommendations for imaging of PA, examines the potential added value that alternative MR sequences and/or CT can offer, and considers how the use of functional/molecular imaging might allow definitive treatment to be recommended for a subset of patients who would otherwise be deemed unsuitable for (further) surgery and/or RT.

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Source
http://dx.doi.org/10.1016/j.beem.2019.05.002DOI Listing

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