Previous studies have suggested that the human Y-chromosome haplogroup Q1a1a-M120, a widespread paternal lineage in East Asian populations, originated in South Siberia. However, much uncertainty remains regarding the origin, diversification, and expansion of this paternal lineage. To explore the origin and diffusion of paternal Q-M120 lineages in East Asia. The authors generated 26 new Y chromosome sequences of Q-M120 males and co-analysed 45 Y chromosome sequences of this haplogroup. A highly-revised phylogenetic tree of haplogroup Q-M120 with age estimates was reconstructed. Additionally, a comprehensive phylogeographic analysis of this lineage was performed including 15,007 samples from 440 populations in eastern Eurasia. An ancient connection of this lineage with populations in Siberia was revealed. However, this paternal lineage experienced an expansion between 5000 and 3000 years ago in northwestern China. Ancient populations with high frequencies of Q-M120 were involved in the formation of ancient Huaxia populations before 2000 years ago; this haplogroup eventually became one of the founding paternal lineages of modern Han populations. This study provides a clear pattern of the origin and diffusion process of haplogroup Q1a1a-M120, as well as the role of this paternal lineage during the formation of ancient Huaxia populations and modern Han populations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/03014460.2019.1632930 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Using uniparental genetic profiles to unravel the complexity of Argentine admixed populations.
Forensic Sci Int Genet
December 2024
DNA Diagnostic Laboratory, Institute of Biology Roberto Alcantara Gomes, State University of Rio de, Rio de Janeiro 20550-900, Brazil.
Latin American countries are distinguished by their highly admixed populations, characterized by a significant preservation of Native American matrilineal ancestry. This contrasts with the paternal lineages, which exhibit different patterns due to pronounced sex-biased mating practices during the colonial period. Uniparental genetic markers have been instrumental in population genetics, facilitating the reconstruction of human settlement histories and serving forensic identification purposes.
View Article and Find Full Text PDFMultiple ancestral components and complex origins of the Yugur people in Gansu province revealing by 35 Y-STR.
Yi Chuan
December 2024
Belt and Road Research Center for Forensic Molecular Anthropology, Gansu University of Political Science and Law, Lanzhou 730000, China.
The Yugur people represent one of the ethnic groups residing within the Hexi Corridor, distinguishable by their small population size, linguistic diversity, intricate ancestral components, serving as a quintessential exemplar of the populations inhabiting this corridor. There are still many controversial issues in the academic community regarding the origin, migration, and formation process of the Yugur. In this study, we explored the formation process of the Yugur from the perspective of molecular anthropology, based on the paternal genetic characteristics of the Yugur people.
View Article and Find Full Text PDFChasing shadows: Investigating X chromosome mediation in late-onset Alzheimer's disease.
Adv Neurol (Singap)
June 2024
Department of Neurology, Tel Aviv University School of Medicine and Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel.
Article Synopsis
- Alzheimer's disease (AD) is a leading cause of dementia, particularly influenced by maternal inheritance but lacking consistent X chromosome risk factors.
- A new analysis method suggested a 70% risk from the X chromosome in patients with amnestic mild cognitive impairment or early AD but did not confirm this in a larger Utah Population Database study due to methodological issues.
- Future studies should focus on identifying X chromosome contributions to late-onset Alzheimer's by looking at newly diagnosed patients rather than relying on data from deceased individuals.
Genetic diversity and polymorphism of genes associated with meat quality and growth traits of A Luoi Yellow cattle in Vietnam.
Vet World
October 2024
Department of Animal Science, Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University, Hue City, Vietnam.
Article Synopsis
- - The study focuses on A Luoi Yellow cattle, a native breed in Vietnam known for its small size, adaptability, and high-quality meat, aiming to enhance breeding genetics using marker-assisted selection for better meat quality and livestock sustainability.
- - Researchers analyzed six key genes related to meat quality using PCR techniques and also explored genetic diversity through mitochondrial DNA and Y chromosome analysis.
- - Results revealed both paternal and maternal origins for the cattle, identified new mtDNA haplotypes, and showed the presence of favorable genetic traits that could support future breeding efforts for improved meat tenderness and overall productivity.
Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition.
Elife
November 2024
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally-induced effects on placenta development and function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!