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Trazodone-gabapentin association increases sedation scores with mild hemodynamic and echocardiographic impact in healthy cats.
Top Companion Anim Med
December 2024
Federal University of Paraná, Palotina, PR, Brazil. Electronic address:
Despite the increasing use of drugs to facilitate feline management in veterinary care, there is still a lack of information on the anxiolytic and sedative effects and their specific physiological impacts. We aimed to compare the sedative, hematological, biochemical and cardiovascular effects of oral single-dose trazodone and gabapentin, alone or in combination, in 8 healthy adult mixed-breed domestic cats on a prospective, randomized, cross-over, and placebo-controlled study. Cats were assigned to receive an oral single dose of trazodone (50 mg) (TG), gabapentin (100 mg) (GG), trazodone (50 mg) and gabapentin (100 mg) (GTG), or placebo (PG).
View Article and Find Full Text PDFPatterns of antidepressant use in people with low back pain: A retrospective study using workers' compensation data.
Eur J Pain
January 2025
Healthy Working Lives Research Group, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Article Synopsis
- * The study analyzed data from LBP claims between 2010 and 2018, focusing on when and how often these medications were dispensed, as well as patterns of switching between different antidepressants.
- * Various factors influenced the dispensing of antidepressants, including demographic aspects like sex and age, prior use of other pain medications, and socioeconomic status, indicating a complex interplay between mental and physical health treatment strategies in this population.
Case series: Cervical far-lateral and combined cervical far lateral/foraminal intervertebral disk extrusions in 10 dogs.
Front Vet Sci
November 2024
Aúna Especialidades Veterinarias IVC Evidensia, Paterna, Spain.
Far-lateral intervertebral disk extrusions (IVDEs) have been reported infrequently in dogs in veterinary literature, mostly affecting the caudal lumbar intervertebral disks. We describe the clinical findings, computed tomography (CT) and magnetic resonance imaging (MRI) findings, treatment, and outcome in 10 dogs with cervical far-lateral IVDEs. Patient databases of 3 small animal hospitals and 1 veterinary teleradiology service were retrospectively searched for patients in which imaging studies (CT or MRI) identified the presence of intervertebral disk material outside the limits of the intervertebral foramen.
View Article and Find Full Text PDFSystematic review of gabapentinoid use during pregnancy and its impact on pregnancy and childhood outcomes: A ConcePTION study.
Therapie
October 2024
Toulouse University Hospital, CERPOP-SPHERE Team, Inserm UMR 1295, Toulouse University, 31000 Toulouse, France.
Objective: In the general population, there has been a noticeable rise in the dispensing of gabapentinoids in recent years. The aim of this study was to provide an overview of all available data on the use and safety of gabapentinoids during pregnancy.
Methods: A systematic review was performed in PubMed and Reprotox using the search terms: "gabapentin", "pregabalin", "antiepileptic drugs" and terms associated with pregnancy.
An overview of the non-procedural treatment options for peripheral neuropathic pain.
Muscle Nerve
November 2024
Department of Physical Medicine and Rehabilitation, University of Rochester Medical Center, Rochester, New York, USA.
Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non-interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology, and lifestyle modification.
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