With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285797 | PMC |
| http://dx.doi.org/10.1002/btpr.2871 | DOI Listing |
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