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Expanding the anti-flaviviral arsenal: Discovery of a baicalein-derived Compound with potent activity against DENV and ZIKV.
Antiviral Res
December 2023
Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School, National University of Singapore, Singapore; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:
With approximately 3.8 billion people at risk of infection in tropical and sub-tropical regions, Dengue ranks among the top ten threats worldwide. Despite the potential for severe disease manifestation and the economic burden it places on endemic countries, there is a lack of approved antiviral agents to effectively treat the infection.
View Article and Find Full Text PDFGIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles.
Biochem Biophys Res Commun
March 2016
Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA; Department of Cell and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA. Electronic address:
Insulin resistance (IR) is a metabolic disorder characterized by impaired glucose uptake in response to insulin. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to be the chief conduit for post-receptor signaling. We recently demonstrated that GIV, a Guanidine Exchange Factor (GEF) for the trimeric G protein, Gαi, is a major hierarchical conduit for the metabolic insulin response.
View Article and Find Full Text PDFThe role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells.
Biochem J
February 1996
Abteilung Klinische Biochemie, Zentrum Innere Medizin der Universität Göttingen, Germany.
Stimulation of secretion by muscarinic agonists in guinea pig parotid or pancreatic acini is accompanied by a translocation of protein kinase C (PKC) from the cytosol to the particulate fraction [Machado-De Domenech and Söling (1987) Biochem. J. 242, 749-754] and by a PKC-mediated phosphorylation of the ribosomal protein S6 [Padel and Söling (1985) Eur.
View Article and Find Full Text PDFNPC 15669-modulated human polymorphonuclear neutrophil functional responsiveness: effects on receptor-coupled signal transduction.
Br J Pharmacol
April 1995
Upjohn Company, Kalamazoo, MI 49001, USA.
1. The effect of NPC 15669, N-carboxy-L-leucine, N-[(2,7-dimethylfluoren-9-yl)methyl]ester), an inhibitor of human polymorphonuclear neutrophil (PMN) adhesion, on granule exocytosis and the oxidative burst was investigated in PMN activated with receptor-specific pathophysiological stimuli. 2.
View Article and Find Full Text PDFMolecular mechanisms of gonadotrophin releasing hormone-stimulated gonadotrophin secretion.
Hum Reprod
November 1993
Department of Obstetrics and Gynaecology, Tübingen, Germany.
Hypothalamic gonadotrophin releasing hormone (GnRH) exerts its effect on gonadotrophin synthesis and release via plasma membrane-bound receptors. The exocytosis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is activated by the binding of GnRH or its agonists to receptors in pituitary cells, which initiates a number of post-receptor events within the gonadotroph cell. Various potential second messengers have been claimed to mediate the stimulatory action of GnRH including calcium, inositol phosphates, protein kinase C, arachidonic acid metabolites and cyclic nucleotides.
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