AI Article Synopsis
- The regeneration of interfacial native tissues is challenging due to their complex composition and structure, necessitating new fabrication techniques.
- A novel mixing system for a double-extruder bioprinter was developed, which incorporates an ultrasonic probe for improved mixing of materials.
- Validation through various characterization methods showed that the new mixing system produces comparable quality samples to traditional manual mixing, indicating its potential in interface-tissue engineering.
Article Abstract
One of the main challenges of the interface-tissue engineering is the regeneration of diseased or damaged interfacial native tissues that are heterogeneous both in composition and in structure. In order to achieve this objective, innovative fabrication techniques have to be investigated. This work describes the design, fabrication, and validation of a novel mixing system to be integrated into a double-extruder bioprinter, based on an ultrasonic probe included into a mixing chamber. To validate the quality and the influence of mixing time, different nanohydroxyapatite-gelatin samples were printed. Mechanical characterization, micro-computed tomography, and thermogravimetric analysis were carried out. Samples obtained from three-dimensional bioprinting using the mixing chamber were compared to samples obtained by deposition of the same final solution obtained by manually operated ultrasound probe, showing no statistical differences. Results obtained from samples characterization allow to consider the proposed mixing system as a promising tool for the fabrication of graduated structures which are increasingly being used in interface-tissue engineering.
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| http://dx.doi.org/10.1177/0391398819852960 | DOI Listing |
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