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| http://dx.doi.org/10.1080/10428194.2019.1627540 | DOI Listing |
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Activation of δ-opioid receptors blocks allodynia in a model of headache induced by PACAP.
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Center for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Background And Purpose: Pituitary adenylate cyclase activating polypeptide (PACAP) is a human migraine trigger that is being targeted for migraine. The δ-opioid receptor (δ-receptor) is a novel target for the treatment of migraine, but its mechanism remains unclear. The goals of this study were to develop a mouse PACAP-headache model using clinically significant doses of PACAP; determine the effects of δ-receptor activation in this model; and investigate the co-expression of δ-receptors, PACAP and PACAP-PAC1 receptor.
View Article and Find Full Text PDFInorganic Mercury Pharmacokinetics in Man: A Hybrid Model.
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Department of Pharmaceutical Sciences, School of Pharmacy, Westcoast University, 590 North Vermont Avenue, Los Angeles, CA 90004.
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Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
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Department of Bacterial Genetics, Institute of Microbiology, Warszawa, Poland.
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Department of Medicine, University of Patras, 26504 Rio, Greece.
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