: This study aimed to analyze the perinatal changes of plasma estradiol (E) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. : Depending on pulmonary arterial pressure, the subjects were divided into two groups, moderate group, and severe group. Plasma concentrations of E and Ang II were determined at different time points using electrochemiluminescence immunoassay and ELISA, respectively. The correlation between E2 and Ang II concentrations was analyzed. : Intragroup comparison indicated that E2 levels at different time points after surgery decreased in the two groups than before, with a greater reduction in the severe group. Besides, both groups showed a reduction in Ang II concentrations after surgery. As indicated by intragroup comparison, there was a significant difference at each time point in the two groups. The reduction in Ang II concentrations was more conspicuous at 48 h and 72 h after surgery (cesarean section) than before for the two groups. Moreover, E concentrations were correlated positively with AngII concentrations. : Plasma concentrations of E and Ang II decreased after delivery. The plasma concentrations of E and Ang II were correlated with each other.
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