Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873773 | PMC |
| http://dx.doi.org/10.1039/c9cc02655j | DOI Listing |
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