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Alkaline phosphatase to treat ischaemia-reperfusion injury in living-donor kidney transplantation: APhIRI I feasibility pilot study.
Br J Clin Pharmacol
December 2023
Dept. of Internal Medicine, Nephrology section, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Aims: Ischemia-reperfusion injury (IRI) during kidney transplant procedures is associated with adverse outcome. Alkaline phosphatase (AP) is an enzyme that has the potential to dampen IRI. Prior to this study, it had not been tested in the setting of kidney transplantation.
View Article and Find Full Text PDFIohexol-Measured Glomerular Filtration Rate and Urinary Biomarker Changes between Vancomycin and Vancomycin Plus Piperacillin-Tazobactam in a Translational Rat Model.
Antimicrob Agents Chemother
August 2023
Midwestern University-Downers Grove Campus, Department of Pharmacy Practice, Downers Grove, Illinois, USA.
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding. This study assessed differences in iohexol-measured glomerular filtration rate (GFR) and urinary injury biomarkers among rats receiving this antibiotic combination.
View Article and Find Full Text PDFIohexol-measured glomerular filtration rate and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model.
bioRxiv
March 2023
Midwestern University- Downers Grove Campus, Department of Pharmacy Practice, Downers Grove, IL, USA.
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding. This study assessed differences in iohexol-measured glomerular filtration rate (GFR) and urinary injury biomarkers among rats receiving this antibiotic combination.
View Article and Find Full Text PDFEvaluating chronic kidney disease in rural South Africa: comparing estimated glomerular filtration rate using point-of-care creatinine to iohexol measured GFR.
Clin Chem Lab Med
July 2021
Department of Chemical Pathology, University of Witwatersrand, Johannesburg, South Africa.
Objectives: The prevalence of chronic kidney disease is rising rapidly in low- and middle-income countries. Serum creatinine and estimation of glomerular filtration rate (GFR) are critical diagnostic tools, yet access to centralised laboratory services remains limited in primary care resource-limited settings. The aim of this study was to evaluate point-of-care (POC) technologies for serum creatinine measurement and to compare their performance to a gold standard measurement using iohexol measured GFR (mGFR).
View Article and Find Full Text PDFIohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods: response to comments from Dr. Luis-Lima.
Pediatr Nephrol
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University of Rochester, Rochester, NY, 14642, USA.
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