Efficient speech communication requires rapid, fluent production of phoneme sequences. To achieve this, our brains store frequently occurring subsequences as cohesive "chunks" that reduce phonological working memory load and improve motor performance. The current study used a motor-sequence learning paradigm in which the generalization of two performance gains (utterance duration and errors) from practicing novel phoneme sequences was used to infer the nature of these speech chunks. We found that performance improvements in duration from practicing syllables with non-native consonant clusters largely generalized to new syllables that contained those clusters. Practicing the whole syllable, however, resulted in larger performance gains in error rates compared to practicing just the consonant clusters. Collectively, these findings are consistent with theories of speech production that posit the consonant cluster as a fundamental unit of phonological working memory and speech sequencing as well as those positing the syllable as a fundamental unit of motor programming.
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http://dx.doi.org/10.1016/j.bandl.2019.05.001 | DOI Listing |
Alzheimers Dement
December 2024
Koc University, Department Biology and Genetics, Istanbul, Turkey.
Background: Valosin Containing Protein (VCP) mutations are responsible some genetic etiologies of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Method: A 67-year-old, male patient, applied to the clinic due to behavioral changes and difficulty swallowing. According the patient history it was reported that his first complaint started 6 years ago (at the age of 61).
Alzheimers Dement
December 2024
Newcastle University, Newcastle upon Tyne, United Kingdom.
Background: Hearing loss is associated with cognitive and neuroimaging markers of Alzheimer's disease dementia but it is unclear how specific measures relate to these after accounting for a range of hearing abilities.
Method: 200 participants (155 cognitively normal, 25 mild cognitively impaired and 20 Alzheimer's disease dementia) underwent auditory testing (peripheral and central abilities), cognitive testing and MR scanning (structural and diffusion-weighted sequences) to evaluate the relationship between hearing, cognition and imaging brain measures.
Result: Central auditory measures such as speech-in-noise perception and auditory memory for longer durations were associated with cognitive impairment across the Alzheimer's disease continuum and specific auditory measures were independently associated with morphometric and diffusion-weighted brain measures.
Alzheimers Dement
December 2024
University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Background: When performing a picture description task, healthy individuals tend to look only briefly at a target before beginning its description, after which they move promptly onto the next target. This sequence may be disrupted in those with cognitive impairment. Just as cognitively impaired individuals produce greater numbers of disfluencies and pauses, those with mild cognitive impairment (MCI) may delay speech production by extending their gaze behavior towards a target before beginning its description.
View Article and Find Full Text PDFClin EEG Neurosci
January 2025
Department of Medical Genetics, Pamukkale University Faculty of Medicine, Denizli, Turkiye.
. This study aims to characterize the clinical phenotype of a family with two siblings exhibiting neurological manifestations, utilizing whole exome sequencing (WES) to identify potential pathogenic variants within the gene. .
View Article and Find Full Text PDFPLoS One
December 2024
Department of Spanish Philology, University of Málaga, Málaga, Spain.
Nasalance is a valuable clinical biomarker for hypernasality. It is computed as the ratio of acoustic energy emitted through the nose to the total energy emitted through the mouth and nose (eNasalance). A new approach is proposed to compute nasalance using Convolutional Neural Networks (CNNs) trained with Mel-Frequency Cepstrum Coefficients (mfccNasalance).
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