AI Article Synopsis
- Cockroaches are key indoor allergens linked to the development of asthma and rhinitis through IgE sensitization.
- This study analyzed antibody levels in 10-year-old children with and without asthma/rhinitis to identify how they react to different cockroach allergens.
- Results showed that higher IgE levels specific to cockroach allergens correlated with asthma and rhinitis, indicating different sensitization patterns among the groups.
Article Abstract
Background: Cockroach is one of the most important sources of indoor allergens and can lead to IgE sensitization and development of rhinitis and asthma.
Objective: We sought to perform a cockroach allergen component analysis to determine the allergens and antibody levels and patterns of sensitization associated with asthma and rhinitis.
Methods: Antibody (IgE, IgG, and IgG) levels to total cockroach and 8 cockroach allergens were determined in 2 groups of cockroach-sensitized 10-year-old children with (n = 19) or without (n = 28) asthma and rhinitis. Allergen-specific antibody levels were measured in streptavidin ImmunoCAPs loaded with each of the recombinant allergens from groups 1, 2, 4, 5, 6, 7, 9, and 11, and total cockroach-specific IgE levels were measured with the i6 ImmunoCAP.
Results: IgE antibody levels to cockroach allergens and extract, but not IgG or IgG antibody levels, differed between subjects with and without asthma and rhinitis. Specifically, recognition of more cockroach allergens with higher allergen-specific IgE levels was associated with disease. Variable patterns of sensitization with no immunodominant allergens were found in both groups. There was a good correlation between the sum of allergen-specific IgE and total cockroach IgE levels (r = 0.86, P < .001).
Conclusions: Component analysis of 8 cockroach allergens revealed significant differences in IgE reactivity associated with the presence of asthma and rhinitis. Allergen-specific IgE titers and sensitization profiles were associated with asthma and rhinitis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307589 | PMC |
| http://dx.doi.org/10.1016/j.jaci.2019.05.036 | DOI Listing |
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