Innate lymphoid cells (ILCs) have attracted considerable attention in the past years. As modulators of epithelial barrier immunology and homeostasis they play important roles in (auto)immunity and inflammation. Here we review the role of ILCs in hematologic malignancies, where ILCs act as efficient killer cells and as tissue healers, in the context of chemotherapy, radiotherapy and after allogeneic hematopoietic stem cell transplantation (HSCT).
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| http://dx.doi.org/10.1016/j.smim.2019.06.002 | DOI Listing |
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Article Synopsis
- Group 1 innate lymphoid cells (ILCs), which include natural killer (cNK) cells and ILC1s, play a key role in both directly killing target cells and regulating the immune environment in the liver, especially in the context of liver tumors.
- The research utilized a specific mouse model to demonstrate how certain transcription factors (like Prdm1) influence the development and function of these immune cells, revealing that although they don't affect cNK cell killing ability, their absence can lead to increased cancer metastasis.
- Findings highlight that Prdm1 is crucial for maintaining functional aspects of cNK cells and ILC1s and their communication with other immune cells, suggesting its potential as a target for new immune therapies against
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