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Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms.
Adv Healthc Mater
January 2025
Department of Biochemistry and Molecular and Cellular Biology, School of Medicine, Georgetown University, Washington, DC, 20057, USA.
Glucocorticoids (GCs) are standard-of-care treatments for inflammatory and immune disorders, and their long-term use increases the risk of osteoporosis. Although GCs decrease bone functionality, their role in bone microvasculature is incompletely understood. Herein, the study investigates the mechanisms of bone microvascular barrier function via osteoblast-endothelial interactions in response to GCs.
View Article and Find Full Text PDFExploring Environmental Microfungal Diversity Through Serial Single Cell Screening.
Mol Ecol Resour
January 2025
Chair of Urban Water Systems Engineering, Technical University of Munich, Garching, Germany.
Known for its remarkable diversity and ecological importance, the fungal kingdom remains largely unexplored. In fact, the number of unknown and undescribed fungi is predicted to exceed the number of known fungal species by far. Despite efforts to uncover these dark fungal taxa, we still face inherent sampling biases and methodological limitations.
View Article and Find Full Text PDFUnveiling the Effect of Age and IgE Level on Alopecia Areata: Insights from Comparative RNAseq Analysis.
Clin Cosmet Investig Dermatol
January 2025
Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, People's Republic of China.
Background: Alopecia areata (AA) is a common autoimmune disease, causes sudden hair loss on the scalp, face, and sometimes other areas of the body. Previous studies have suggested more severe manifestations and higher recurrence rates in children than in adults. Moreover, pediatric AA patients with atopic predisposition often exhibit elevated IgE levels, early onset, and a poor prognosis.
View Article and Find Full Text PDFFuel for thought: targeting metabolism in lung cancer.
Transl Lung Cancer Res
December 2024
Department of Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.
For over a century, we have appreciated that the biochemical processes through which micro- and macronutrients are anabolized and catabolized-collectively referred to as "cellular metabolism"-are reprogrammed in malignancies. Cancer cells in lung tumors rewire pathways of nutrient acquisition and metabolism to meet the bioenergetic demands for unchecked proliferation. Advances in precision medicine have ushered in routine genotyping of patient lung tumors, enabling a deeper understanding of the contribution of altered metabolism to tumor biology and patient outcomes.
View Article and Find Full Text PDFTuning Optical Properties of Organic Thin Films through Intermolecular Interactions - Fundamentals, Advances and Strategies.
Chemistry
January 2025
IPHT: Leibniz-Institut fur Photonische Technologien, Institute for Physical Chemistry, Albert-Einstein-Str. 9, 07745, Jena, GERMANY.
In applications ranging from photon-energy conversion into electrical or chemical forms (such as photovoltaics or photocatalysis) to numerous sensor technologies based on organic solids, the role of supramolecular structures and chromophore interactions is crucial. This review comprehensively examines the critical intermolecular interactions between organic dyes and their impact on optical properties. We explore the range of changes in absorption or emission properties observed in molecular aggregates compared to single molecules.
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