Background: Food protein-induced enterocolitis syndrome or FPIES is a rare, not-IgE-mediated food allergy. The predominant feature is vomit from one to four hours after consuming the causal food.
Clinical Case: An 8-month-old boy, with no family history of allergy, with a personal pathological history of allergy to cow's milk protein. At 7 months of age, he had acute gastroenteritis with mixed shock and, at 8 months of age, he had acute gastroenteritis and moderate dehydration. In both episodes, he had eaten rice before the symptoms started. When infectious etiology and other causes of vomit and dehydration were ruled out, the diagnosis of FPIES, which is secondary to rice protein, was made and confirmed with a patch test.
Conclusion: FPIES should be considered in the differential diagnosis of recurrent gastroenteritis, especially in severe cases without an identified infectious cause.
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Food protein induced enterocolitis syndrome: French practices assessment in children.
Arch Pediatr
January 2025
Sorbonne Université, Paediatric Nutrition and Gastroenterology Department, APHP-Trousseau Hospital, 26 avenue du Dr Arnold Netter, 75012 Paris, France. Electronic address:
Background: Food protein-induced enterocolitis syndrome (FPIES) is a specific non IgE-mediated food allergy. The international consensus guidelines defined diagnosis criteria and management plan in 2017.
Objectives: To assess practices regarding FPIES in France and in French-speaking countries, according to those guidelines.
The Non-Food-Specific Dynamics for Tolerance Acquisition in Acute Food Protein-Induced Enterocolitis Syndrome.
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Department of Pediatrics, Seirei Numazu Hospital, 902-6, Matsushitahichitanda, Numazu City, Shizuoka 410-0867, Japan. Electronic address:
The role of IgE sensitisation in acute FPIES: A systematic review and meta-analysis.
J Allergy Clin Immunol Pract
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Section of Inflammation, Repair and Development, National Heart and Lung Institute. Imperial College London, UK.
Background: Evidence on the role of IgE sensitisation in acute Food Protein-Induced Enterocolitis Syndrome ('atypical FPIES') is limited. Initial reports claimed association with persistent disease, however recent studies have not replicated this.
Objective: To systematically review the relationship between sensitisation to the culprit food(s) in acute FPIES and the outcome of follow-up oral food challenges.
Management of children with food allergies by allergists in the United States.
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the Department of Pediatrics, New York University Grossman School of Medicine, New York, NY.
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Objective: Our aim was to investigate the management patterns and educational needs of practicing allergists treating patients with food allergies.
Severity trend of recurrence in pediatric Food Protein-Induced Enterocolitis Syndrome (FPIES).
J Allergy Clin Immunol Pract
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Pediatric Allergy Unit, Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, 00168 Rome, Italy. Electronic address:
Background: Reintroduction of offending food in pediatric patients affected by Food Protein-Induced Enterocolitis Syndrome (FPIES) is carried out in hospitals with Oral Food Challenge (OFC), which leads to long waiting time and increases the societal burden of medical cost and human resources.
Objective: The aim of the study is to assess severity trend of acute FPIES adverse reactions over time in the same patient for possible outpatient or home reintroduction of offending food.
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