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The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer-Induced Lymphatic Metastasis and Lymphangiosarcoma.
Cancer Rep (Hoboken)
January 2025
Department of Plastic, Hand, and Reconstructive Microsurgery, BG Unfallklinik Frankfurt Am Main, Affiliated Hospital of Goethe-University, Frankfurt am Main, Germany.
Background: Malignant tumors release growth factors, promoting lymphangiogenesis in primary tumors and draining sentinel lymph nodes, ultimately facilitating lymph node metastasis. As a malignant lymphatic tumor entity, lymphangiosarcomas are characterized by low survival rates and limited treatment options. The transcription factor SOX18 plays a crucial role in both lymphatic endothelial cell differentiation and cancer-induced lymphangiogenesis.
View Article and Find Full Text PDF[Progress on the role of N-end rule pathways in protein degradation].
Sheng Li Xue Bao
December 2024
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000, China.
The N-end rule pathway is a protein degradation pathway mediated by the ubiquitin-proteasome system, which specifically targets and degrades target proteins by recognizing specific residues at the N-terminus of the proteins. The residues which play a crucial role in the N-end rule pathway are called degrons, also known as N-degrons, as they are usually unstable at the N-terminal end of the protein. Currently, several N-end rule pathways have been identified in the eukaryotes, including the Arg/N-end rule, Ac/N-end rule, and Pro/N-end rule pathways, as well as the recently discovered Gly/N-end rule pathway.
View Article and Find Full Text PDFQuantitatively Detecting Camellia Oil Products Adulterated by Rice Bran Oil and Corn Oil Using Raman Spectroscopy: A Comparative Study Between Models Utilizing Machine Learning Algorithms and Chemometric Algorithms.
Foods
December 2024
School of Physical Science and Technology, Tiangong University, Tianjin 300387, China.
The fast and accurate quantitative detection of camellia oil products is significant for multiple reasons. In this study, rice bran oil and corn oil, whose Raman spectra both hold great similarities with camellia oil, are blended with camellia oil, and the concentration of each composition is predicted by models with varying feature extraction methods and regression algorithms. Back propagation neural network (BPNN), which has been rarely investigated in previous work, is used to construct regression models, the performances of which are compared with models using random forest (RF) and partial least squares regression (PLSR).
View Article and Find Full Text PDFReal-Time Volumetric Free-Hand Ultrasound Imaging for Large-Sized Organs: A Study of Imaging the Whole Spine.
Ultrasound Med Biol
January 2025
Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
Article Synopsis
- The study presents a new real-time volumetric free-hand ultrasound imaging system designed to improve 3D imaging for large organs, specifically addressing challenges like long acquisition times and patient movement.
- The system employs an incremental imaging technique and two tissue segmentation algorithms to enhance feature recognition and visualize spinal anatomy in 3D.
- Validation tests on various ultrasound models and experiments with scoliosis patients showed promising results, indicating a high correlation with X-ray images and suggesting potential for broader clinical applications.
Extensor tendon injuries are commonly encountered after trauma. These injuries often result in acute weakness and have widely differing treatment options depending on the severity and the location of the injury within the upper extremity. Zone I injuries can often be treated nonoperatively with the potential for pinning of any large bony avulsion fragments.
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