Identifying and supporting specific organ procurement organizations (OPOs) with the greatest opportunity to increase donation rates could significantly increase the number of organs available for transplant. Accomplishing this is complicated by current Scientific Registry of Transplant Recipients/Centers for Medicare & Medicaid Services metrics of donation rates and OPO performance that rely on eligible deaths. These data are self-reported and unverifiable and have been shown to underestimate potential organ donors. We examine the limitations of current OPO performance/donation metrics to inform discussions related to strategies to increase donation. We propose changing to a simple, verifiable, and uniformly applied donation metric. This would allow the transplant community to (1) better understand inherent differences in donor availability based on geography and (2) identify underperforming areas that would benefit from systems improvement agreements to increase donation rates.
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http://dx.doi.org/10.1111/ajt.15492 | DOI Listing |
Background: Catch-up HPV vaccination is challenging in many low and middle-income countries (LMICs). Pay-it-forward offers an individual a subsidized vaccine, then an opportunity to donate to help others access vaccinations. Our randomized control trial assessed the effectiveness of pay-it-forward in improving HPV vaccination among girls aged 15-18 years in China.
View Article and Find Full Text PDFCardiovasc Toxicol
January 2025
Department of Cadre Ward, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Harbin, 150001, Heilongjiang, PR China.
Atherosclerosis risk is elevated in diabetic patients, but the underlying mechanism such as the involvement of macrophages remains unclear. Here, we investigated the underlying mechanism related to the pro-inflammatory activation of macrophages in the development of diabetic atherosclerosis. Bioinformatics tools were used to analyze the macrophage-related transcriptome differences in patients with atherosclerosis and diabetic mice.
View Article and Find Full Text PDFUltrasound Med Biol
January 2025
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan ROC; Center of Physical Therapy, National Taiwan University Hospital, Taipei, Taiwan ROC. Electronic address:
Objective: This study aimed to validate the ultrasound speckle tracking (UST) algorithm, determine the optimal probe location by comparing normalized cross-correlation (NCC) values of muscle displacement at two locations (proximal vs. middle) of the biceps femoris long head (BFlh) using the UST, and investigate the effects of Nordic hamstring curl exercise (NHE) training on BFlh displacement.
Methods: UST efficacy was verified with ex vivo uniaxial testing of porcine leg muscles.
J Colloid Interface Sci
January 2025
College of Materials Science and Engineering, Hunan University, Changsha 410082 PR China. Electronic address:
Although MXenes have attracted significant attention across diverse fields, they exhibit a pronounced susceptibility to oxidation in aqueous environments, with oxidation significantly accelerated in the presence of transition metal ions (TMI) such as Fe and Cu. This limitation impedes the synthesis of transition metal compounds/MXene-based composites and their potential for functional applications. In this study, we elucidate the mechanism of accelerated oxidation of TiCT is that Fe promotes the electron loss in TiCT, thus leading to an increased production of hydroxyl radicals (OH) to oxidize TiCT.
View Article and Find Full Text PDFCell Transplant
January 2025
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Pediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal organ donation could potentially ameliorate the discrepancy but is currently not implemented in Sweden. This study aims to evaluate the potential of neonatal organ donation in central Sweden using a standardized protocol with organ specific criteria.
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