Background: The correlation between () and gastroesophageal reflux disease (GERD) is complex. Some studies showed a protective role of infection against GERD. This study was aimed at assessing the role of infection in GERD utilizing a large cohort of patients diagnosed with GERD.
Methods And Materials: All patients who underwent gastroscopy for an indication of GERD during the study period between 2015 and 2017 at the EMMS Nazareth Hospital were considered eligible for the study and therefore were included. infection was determined by the rapid urease test or histology. Severity of esophagitis was assessed using the Los Angeles classification. Univariate analysis was performed to figure out differences between patients according to infection status. Multivariate regression analysis was conducted to illustrate the predictors of positivity for infection.
Results: 2,508 GERD patients were included with a median age of 49.42 ± 17.96 years. infection was detected in 299 (11.9%) patients. GERD patients with infection were found to be younger (48.83 ± 17.42 years versus 44.57 ± 17.69 years, < 0.001), have the tendency to smoke more (1406 (63.6%) versus 266 (89.0%), < 0.001), and use more proton pump inhibitors or PPIs (1314 (59.5%) versus 242 (80.9%), < 0.001). In multivariate regression analysis, age (OR 0.987, < 0.001), smoking status (OR 0.190, < 0.001), use of ASA/NSAIDs (OR 1.652, = 0.004), and use of statins (OR 0.499 (95%CI 0.295-0.846), = 0.010) were found significant among -positive individuals. -positive subjects have less severe esophagitis and more hiatus hernia.
Conclusion: Patients with GERD and infection were significantly younger, tended to smoke more, and used more PPIs and had significantly lower grades of esophagitis compared to noninfected ones.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526568 | PMC |
| http://dx.doi.org/10.1155/2019/3819893 | DOI Listing |
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