Mutagenic and cytostatic activities of the essential oil in human lymphocytes.

Nat Prod Res

Departamento de Biotecnology, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil.

Published: May 2021

Hydro-distilled essential oil from leaves of was characterized by GC-MS. Twenty-seven components were identified and the oil's major constituents comprised germacrene D, bicyclogermacrene, (-caryophyllene and germacrene B. The cytotoxicity of the essential oil of (EOXL), determined by MTT and mitotic index methods in cultured human lymphocytes was observed in all tested concentrations. Cultures treated with EOXL demonstrated significant increase in the frequencies of micronuclei in the cytokinesis-block micronucleus assay (CBMN) and reduction of the cytokinesis-block proliferation index (CBPI) rates. Results demonstrated the cytostatic and mutagenic effects of EOXL, the latter for the first time.

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http://dx.doi.org/10.1080/14786419.2019.1624956DOI Listing

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