Three previously undescribed -dammarane triterpenoid glycosides O-Q () along with two known compounds ( and ) were isolated and characterized from the leaves of . Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P () showed somewhat inhibitory activity towards those tumor cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2019.1616722 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mechanism of sodium nitroprusside regulating ginseng quality.
Sci Rep
January 2025
Department of Pharmacognosy, Heilongjiang University of Chinese Medicine, Harbin, 150040, Hei-longjiang, China.
The roots of Panax ginseng C. A. Meyer (ginseng) are one of the traditional medicinal herbs in Asian countries and is known as the "king of all herbs".
View Article and Find Full Text PDFGenome-Wide Identification and Characterization of Gene Family in (Cucurbitaceae).
Life (Basel)
December 2024
Xi'an Botanical Garden of Shaanxi Province, Institute of Botany of Shaanxi Province, No. 17 Cuihua South Road, Xi'an 710061, China.
is a traditional Chinese medicinal plant of considerable application value and commercial potential, primarily due to its production of various bioactive compounds, particularly dammarane-type triterpenoid saponins that are structurally analogous to ginsenosides. Oxidosqualene cyclase (OSC), a pivotal enzyme in the biosynthesis of triterpenoid metabolites in plants, catalyzes the conversion of oxidosqualene into triterpenoid precursors, which are essential components of the secondary metabolites found in . To elucidate the role of gene family members in the synthesis of gypenosides within , this study undertook a comprehensive genome-wide identification and characterization of genes within and compared their expression levels across populations distributed over different geographical regions by both transcriptome sequencing and qRT-PCR experimental validation.
View Article and Find Full Text PDFEnrichment of Ginseng Rare Sapogenin 25-OH-PPT and Its Protective Effect on Myocardial Fibrosis.
Molecules
December 2024
School of Functional Food & Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Article Synopsis
- Ginseng contains rare compounds called ginsenosides, specifically 25-OH-PPT (T19), known for beneficial effects like lowering blood sugar and reducing inflammation.
- The research focused on optimizing the process to extract T19 from ginseng stems and leaves, utilizing different acids and hydrolysis conditions to maximize yield safely.
- Results showed that hydrochloric acid increased T19 content significantly, while citric acid was safer; additionally, T19 demonstrated protective effects on heart cells by reducing oxidative stress and impacting fibrosis markers.
Existing Forms of Notoginsenoside R in Rats and Their Potential Bioactivities.
J Agric Food Chem
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Article Synopsis
- - Notoginsenoside R (NG-R), a key saponin in a medicinal plant, was analyzed using advanced UHPLC-ESI-Q-TOF-MS/MS techniques to identify its various forms and distribution in rats, resulting in the detection of 105 metabolites, including 89 new ones.
- - The study proposed a new fragmentation pathway for protopanaxatriol (PPT) and revealed novel metabolic reactions for NG-R, such as polyhydroxylation and glucuronidation, with significant metabolite accumulation observed in various organs.
- - Predictive analyses suggested 48 metabolites may have therapeutic effects on three diseases, with follow-up experiments confirming anti-tumor and anti-inflammatory properties in eight specific
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!