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Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth.
Nat Commun
October 2024
KU Leuven, Department of Mechanical Engineering, Biomechanics section, Leuven, Belgium.
Article Synopsis
- - The study investigates how cellular interactions, driven by force, contribute to cancer cell invasion, particularly in the context of cerebral cavernous malformations (CCM), which are characterized by abnormal blood vessels.
- - Researchers used an in-vitro model to demonstrate that endothelial cells lacking the CCM2 protein help recruit normal (wild-type) endothelial cells through mechanical forces and changes in the surrounding extracellular matrix, facilitating lesion growth.
- - The findings reveal that CCM2 mutant cells manipulate neighboring wild-type cells into proliferating and altering their functions, providing new insights into the mechanisms behind vascular abnormalities and tools for studying cell behavior in disease contexts.
Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen.
Sci Rep
February 2021
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
Traction force microscopy (TFM) is an important family of techniques used to measure and study the role of cellular traction forces (CTFs) associated with many biological processes. However, current standard TFM methods rely on imaging techniques that do not provide the experimental capabilities necessary to study CTFs within 3D collective and dynamic systems embedded within optically scattering media. Traction force optical coherence microscopy (TF-OCM) was developed to address these needs, but has only been demonstrated for the study of isolated cells embedded within optically clear media.
View Article and Find Full Text PDFPulling the springs of a cell by single-molecule force spectroscopy.
Emerg Top Life Sci
May 2021
Biophysics and Structural Genomics, Saha Institute of Nuclear Physics, Kolkata 700064, West Bengal, India.
The fundamental unit of the human body comprises of the cells which remain embedded in a fibrillar network of extracellular matrix proteins which in turn provides necessary anchorage the cells. Tissue repair, regeneration and reprogramming predominantly involve a traction force mediated signalling originating in the ECM and travelling deep into the cell including the nucleus via circuitry of spring-like filamentous proteins like microfilaments or actin, intermediate filaments and microtubules to elicit a response in the form of mechanical movement as well as biochemical changes. The 'springiness' of these proteins is highlighted in their extension-contraction behaviour which is manifested as an effect of differential traction force.
View Article and Find Full Text PDFTraction force-mediated B cell activation: how and why.
Sci China Life Sci
July 2019
MOE Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Beijing Key Lab for Immunological Research on Chronic Diseases, Institute for Immunology, Tsinghua University, Beijing, 100084, China.
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion.
Nat Commun
September 2016
Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an active metabolite of vitamin A, restores mechanical quiescence in PSCs via a mechanism involving a retinoic acid receptor beta (RAR-β)-dependent downregulation of actomyosin (MLC-2) contractility.
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