Purpose: This paper deals with the kinematic modelling of an arm exoskeleton used for human rehabilitation. The biomechanics of the arm was studied and the 9 Degrees of Freedom model was obtained. The particular (optimal) exoskeleton arm configuration is needed, depending on patient abilities and possibility or other users activity.
Methods: The model of upper arm was obtained by using Denavit-Hartenberg notation. The exoskeleton human arm was modelled in MathWorks package. The multicriteria optimization procedure was formulated to plan the motion of trajectory. In order to find the problem solution, an artificial intelligence method was used.
Results: The optimal solutions were found applying a genetic algorithm. Two variants of motion with and the visualization of the change of joints angles were shown. By the use of genetic algorithms, movement trajectory with the Pareto-optimum solutions has been presented as well. Creating a utopia point, it was possible to select only one solution from Pareto-optimum results.
Conclusions: The obtained results demonstrate the efficiency of the proposed approach that can be utilized to analyse the kinematics and dynamics of exoskeletons using the dedicated design process. Genetic algorithm solution could be implemented to command actuators, especially in the case of multi-criteria problems. Moreover, the effectiveness of this method should be evaluated in the future by real experiments.
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Protein Sci
February 2025
Department of Physics, University of Washington, Seattle, Washington, USA.
Proteins' flexibility is a feature in communicating changes in cell signaling instigated by binding with secondary messengers, such as calcium ions, associated with the coordination of muscle contraction, neurotransmitter release, and gene expression. When binding with the disordered parts of a protein, calcium ions must balance their charge states with the shape of calcium-binding proteins and their versatile pool of partners depending on the circumstances they transmit. Accurately determining the ionic charges of those ions is essential for understanding their role in such processes.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, China.
Background: Immunotherapy is a significant risk factor for severe COVID-19 in multiple myeloma (MM) patients. Understanding how immunotherapies lead to severe COVID-19 is crucial for improving patient outcomes.
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Sci Rep
January 2025
Departments of Breast Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu, People's Republic of China.
The impact of mitochondrial and lysosomal co-dysfunction on breast cancer patient outcomes is unclear. The objective of this study is to develop a predictive machine learning (ML) model utilizing mitochondrial and lysosomal co-regulators in order to provide a foundation for future studies focused on breast cancer (BC) patients' stratification and personalized interventions. Firstly, Differences and correlations of mitochondrial and lysosome related genes were screened and validated by differential analysis, copy number variation (CNV), single nucleotide polymorphism (SNPs) and correlation analysis.
View Article and Find Full Text PDFOncology
January 2025
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Introduction: Temozolomide (TMZ) is a widely used chemotherapy agent for the treatment of malignant gliomas and other brain tumors. Despite its established therapeutic benefits, there is an ongoing need to understand better its safety profile, particularly in real-world clinical settings. This study aimed to identify critical adverse drug reactions (ADRs) associated with TMZ by utilizing the FDA Adverse Event Reporting System (FAERS) database, thereby providing valuable safety insights for clinical practice.
View Article and Find Full Text PDFZoology (Jena)
January 2025
Laboratory of Ecology and Environmental Management, Science and Technology Advanced Institute, Van Lang University, Ho Chi Minh City, Vietnam; Faculty of Applied Technology, School of Technology, Van Lang University, Ho Chi Minh City, Vietnam. Electronic address:
Floods, which occur when the amount of precipitation surpasses the capacity of an area to drain it adequately, have detrimental consequences on the survival and future generations of fishes. However, few works have reported the prediction of this natural phenomenon in a relation to certain fish species, especially in fast-flowing rivers. In the specific context of the northern mountainous provinces of Vietnam, where the Spinibarbus sp.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!