The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Individuals with idiopathic PD who were ≥50 years old and free of surgical procedures for PD were recruited. Participants were assigned to either a cycling ( = 20) or control ( = 15) group. The cycling group completed three sessions of high cadence cycling on a custom motorized stationary ergometer. The primary outcome was cognition (attention, executive function, and emotion recognition were assessed via WebNeuro and global cognition via Montreal Cognitive Assessment). Depression symptoms were assessed via Beck Depression Inventory-II. There was a main effect of time for emotional recognition ( = 0.048), but there were no other changes in cognition or depression symptoms. Regardless of intervention or Val66Met polymorphism, high cadence cycling does not alter cognition or depression symptoms after three sessions in one week.
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http://dx.doi.org/10.3390/ijerph16122104 | DOI Listing |
Brain Sci
December 2024
Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.
Background/objectives: Cognitive functions are a crucial part of daily living, especially for adults with Down syndrome (DS) who have a high likelihood of developing Alzheimer's disease in adulthood. In addition, adults with DS move slower and are not meeting the standard aerobic activity guidelines each week. The aim of this study was to examine if Assisted Cycle Therapy (ACT) would improve cognitive planning as measured by the Tower of London (TOL), set switching as measured by the modified Wisconsin Card Sorting Test, and spatial memory as measured by the Corsi Block Test in adults with DS as compared to self-paced cycling.
View Article and Find Full Text PDFNature
January 2025
Southwest Research Institute, San Antonio, TX, USA.
Chorus waves are some of the strongest electromagnetic emissions naturally occurring in space and can cause radiation that is hazardous to humans and satellites. Although chorus waves have attracted extreme interest and been intensively studied for decades, their generation and evolution remain highly debated. Here, in contrast to the conventional expectation that chorus waves are governed by planetary magnetic dipolar fields, we report observations of repetitive, rising-tone chorus waves in the terrestrial neutral sheet, where the effects of the magnetic dipole are absent.
View Article and Find Full Text PDFBackground: Running-related overuse injuries are common among recreational runners; however, there is currently little prospective research investigating the role of running characteristics on overuse injury development.
Purpose: To investigate the relationship between running characteristics and lower extremity musculoskeletal injury (MSKI).
Study Design: Cohort study; Level of evidence, 2.
Mult Scler Relat Disord
January 2025
Department of Neurology and Neurological Rehabilitation, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 201619, China. Electronic address:
Background: Three-dimensional (3D) gait analysis has the potential to assess dynamic spasticity (DS). However, little is known about which parameters can be utilized for assessment.
Objective: To evaluate the application of 3D gait analysis in assessing DS during walking and to identify the most relevant parameters for clinical practice.
Curr Med Imaging
January 2025
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong An Road, Xicheng District, Beijing 100050, China.
Background: The neuroanatomical basis of white matter fiber tracts in gait impairments in individuals suffering from Parkinson's Disease (PD) is unclear.
Methods: Twenty-four individuals living with PD and 29 Healthy Controls (HCs) were included. For each participant, two-shell High Angular Resolution Diffusion Imaging (HARDI) and high-resolution 3D structural images were acquired using the 3T MRI.
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