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Translating time: Challenges, progress, and future directions.
Brain Res Bull
January 2025
Department of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. Electronic address:
Mice are the dominant model system to study human health and disease. Yet, there is a pressing need to use diverse model systems to address long-standing issues in biomedical sciences. Mice do not spontaneously recapitulate many of the diseases we seek to study.
View Article and Find Full Text PDFComparative lifespan and healthspan of nonhuman primate species common to biomedical research.
Geroscience
November 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed in 12 translational aging models: baboon, bonnet macaque, chimpanzee, common marmoset, coppery titi monkey, cotton-top tamarin, cynomolgus macaque, Japanese macaque, pigtail macaque, rhesus macaque, squirrel monkey, and vervet/African green. After employing strict inclusion criteria, primary results are based on 12,269 NHPs that survived to adulthood and died of natural/health-related causes.
View Article and Find Full Text PDFGreat ape surveys and the implications of long-term monitoring in the Djéké Triangle, Republic of Congo.
Primates
November 2024
Wildlife Conservation Society, Congo Program, B.P. 14537, Brazzaville, Republic of Congo.
Existing protected areas are anchors for conservation. Safeguarding flora and fauna within their peripheral areas is essential to maintaining their integrity and to potential increases to the area under effective conservation. With the decline in tropical forests, initiatives to increase the area of undisturbed forests under strict protection, particularly those neighboring protected areas, is of critical importance.
View Article and Find Full Text PDFA brief history of primate research in the Ndoki forest.
Primates
November 2024
Wildlife Conservation Society, Congo Program, B.P. 14537, Brazzaville, Republic of Congo.
Article Synopsis
- The Nouabalé-Ndoki National Park in the Republic of Congo is a important place for saving animals and plants, especially primates, in Central Africa.
- Scientists have set up special stations to study how primates behave in different environments and are using new technology to help their research.
- Despite successes, there are still worries about the future of primates and their homes, so working with local communities is essential for protecting the forests for many years to come.
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research.
bioRxiv
November 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Article Synopsis
- There is a significant need to create age- and sex-specific survival curves for nonhuman primates (NHP) in biomedical research to better understand aging.
- A study analyzed data from over 110,000 captive NHP to generate survival curves for various species, reporting meaningful differences in lifespans and health based on sex and species type.
- Results indicated that male NHP, particularly among certain African and Asian species, had reduced survival rates, and median lifespans were often lower than what was previously documented, suggesting these analyses may more accurately reflect healthspan rather than just lifespan.
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