Recently, the methylene-cycloakylacetate (MCA) scaffold has been reported as a potential pharmacophore for neurite outgrowth activity. In this work, natural diterpenes that embed MCA fragments are reviewed, as they are major components of : -halimic acid, the prototype for these bioactive compounds. Herein, structures, sources, and activities for the natural diterpenes, as well as their synthetic derivatives of interest, are reviewed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600407 | PMC |
| http://dx.doi.org/10.3390/molecules24112120 | DOI Listing |
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