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| http://dx.doi.org/10.1016/j.cnp.2019.04.003 | DOI Listing |
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The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.
Database (Oxford)
January 2025
Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium.
The European Union's ban on animal testing for cosmetic products and their ingredients, combined with the lack of validated animal-free methods, poses challenges in evaluating their potential repeated-dose organ toxicity. To address this, innovative strategies like Next-Generation Risk Assessment (NGRA) are being explored, integrating historical animal data with new mechanistic insights from non-animal New Approach Methodologies (NAMs). This paper introduces the TOXIN knowledge graph (TOXIN KG), a tool designed to retrieve toxicological information on cosmetic ingredients, with a focus on liver-related data.
View Article and Find Full Text PDFAuditory Global-Local Processing Under Tonal Language Background: Effect of Attention and Autistic Traits.
J Speech Lang Hear Res
January 2025
Speech-Language-Hearing Center, School of Foreign Languages, Shanghai Jiao Tong University, China.
Purpose: Neurotypical individuals show a robust "global precedence effect (GPE)" when processing hierarchically structured visual information. However, the auditory domain remains understudied. The current research serves to fill the knowledge gap on auditory global-local processing across the broader autism phenotype under the tonal language background.
View Article and Find Full Text PDF[Association between occupational exposure to pesticides and ototoxicity in farmers of Pontal do Paranapanema-SP, Brazil].
Cien Saude Colet
January 2025
Departamento de Química, Universidade do Oeste Paulista. São Paulo SP Brasil.
The scope of this study was to assess the ototoxic effects and general health of farmers exposed to pesticides in the Pontal do Paranapanema region, SP, Brazil. Participants of both sexes aged 18-40, 40-60 and >60 years were allocated into two groups: Non-Exposed Group (NEG) and Occupationally Exposed Group (OEG). A questionnaire of exposure and health, meatoscopy, pure tone audiometry, logoaudiometry and immittanciometry were assessed.
View Article and Find Full Text PDFRGB sensor integrated into unmanned aerial vehicle for monitoring cyanobacterial density in reservoirs.
Integr Environ Assess Manag
January 2025
Federal University of the Agreste of Pernambuco, Garanhuns, Brazil.
The proliferation of cyanobacteria has become a significant water management challenge due to the increasing eutrophication of water supply reservoirs. Cyanobacterial blooms thrive on elevated nutrient concentrations and form extensive green mats, disrupting the local ecosystem. Furthermore, many cyanobacterial species can produce toxins that are lethal to vertebrates called cyanotoxins.
View Article and Find Full Text PDFPreclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-drug conjugate (Trodelvy) for imaging in gastric cancer and triple-negative breast cancer.
Eur J Nucl Med Mol Imaging
January 2025
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Purpose: Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progression, while its expression remains low in normal tissues. Trop2-targeting antibody-drug conjugate (ADC), sacituzumab govitecan-hziy (Trodelvy), has shown efficacy in targeting this antigen. Leveraging the enhanced specificity of ADCs, we conducted the first immunoPET imaging study of Trop2 expression in gastric cancer (GC) and triple-negative breast cancer (TNBC) models using Zr-labeled Trodelvy ([Zr]Zr-DFO-Trodelvy).
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