AI Article Synopsis
- HIV-infected and HIV-exposed uninfected (HEU) children face higher measles risks, likely due to immune response differences and vaccination timing issues.
- A systematic review included 71 studies with over 15,000 children, revealing that while adverse vaccine effects were rare, HIV-infected kids had lower immune response rates than non-infected children, though these could improve with antiretroviral therapy.
- Vaccinating at 6 months old appears effective for both HIV-infected and HEU children, showing similar immune responses to non-infected children, suggesting the need for more research in high maternal HIV-infection areas.
Article Abstract
Background: HIV-infected and HIV-exposed uninfected (HEU) children have an increased risk of measles that may be due to altered immune responses or suboptimal timing of measles vaccination. We aimed to evaluate the safety and immunogenicity of measles vaccination in HIV-infected and HEU children.
Methods: For this systematic review and meta-analysis, we searched PubMed, Embase, Cochrane Library, CINAHL, Global Health Library and IndMED on May 9, 2018. Studies were included if they reported on safety or seroresponse (either seroprotection/seropositivity/seroconversion) after measles vaccination in HIV-infected or HEU children. We calculated pooled estimates to compare immunogenicity outcomes between HIV-infected, HEU and HIV-unexposed children, using risk ratios [RRs] (with 95%CIs). PROSPERO registration number: CRD42017057411.
Findings: Seventy-one studies met the inclusion criteria (15,363 children). Twenty-eight studies reported on safety; vaccine-associated adverse events and deaths were uncommon. Sixty-two studies reported on immunogenicity, 27 were included in the meta-analysis. HIV-infected children had lower seroresponse rates after primary vaccination compared with HIV-unexposed (RR 0.74; 95%CI: 0.61-0.90, = 85.9%) and HEU children (0.78; 0.69-0.88, = 77.1%), which was mitigated by antiretroviral therapy and time interval between vaccination and serology. HEU and HIV-unexposed children had similar seroresponses. Vaccination at 6-months resulted in similar proportions of HIV-infected children having seroresponse compared with HIV-unexposed (0.96; 0.77-1.19) and HEU children (1.00; 0.73-1.37, = 63.7%).
Interpretation: Primary measles vaccination at 6-months of age may provide protection against measles during early infancy in settings with high prevalence of maternal HIV-infection, however, further studies are needed to evaluate this strategy in HEU children and HIV-infected children receiving antiretroviral therapy.
Funding: South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation in Vaccine Preventable Diseases; Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537570 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2018.06.002 | DOI Listing |
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